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Leucemia Mielóide Aguda t(8;21) após tratamento de hipertiroidismo com iodo radioativo: Leucemia secundária?
- Source :
- Revista Brasileira de Hematologia e Hemoterapia, Volume: 24, Issue: 2, Pages: 137-138, Published: APR 2002
- Publication Year :
- 2002
- Publisher :
- Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2002.
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Abstract
- Acute leukemia following treatment with Iodine131 is a rare event. The possible carcinogenic effect of Iodine131 is still not clear and a large series of cases did not show an increased incidence of cancer. A case of AML t(8;21), three years after Iodine131 treatment for hyperthyroidism, is reported. Secondary AML with t(8;21) is described following exposure to drugs that target topoisomerase II and radiotherapy. The controversial potential of Iodine131 as a leukemogenic agent and the fact that t(8;21) is also found in de-novo AML, emphasize the problem in establishing a relationship between these events although this potential can not be ruled out.
- Subjects :
- hemic and lymphatic diseases
Subjects
Details
- Language :
- Portuguese
- Database :
- OpenAIRE
- Journal :
- Revista Brasileira de Hematologia e Hemoterapia, Volume: 24, Issue: 2, Pages: 137-138, Published: APR 2002
- Accession number :
- edsair.od.......608..47ca8f4e9ce5398359ce3fc6bb02b172