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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
- Source :
- Molecular psychiatry, vol 26, iss 9
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
- Subjects :
- Adult
Male
Aging
Adolescent
Major Depressive Disorder
Medical and Health Sciences
Young Adult
Clinical Research
2.3 Psychological
Behavioral and Social Science
Humans
Longitudinal Studies
Aetiology
Aged
Psychiatry
Depressive Disorder
Depression
Psychology and Cognitive Sciences
Neurosciences
Brain
Major
Middle Aged
Biological Sciences
Serious Mental Illness
Magnetic Resonance Imaging
Brain Disorders
Mental Health
Biomedical Imaging
Female
social and economic factors
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Molecular psychiatry, vol 26, iss 9
- Accession number :
- edsair.od.......325..f0701503e202e31764c0a53afb622338