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Alanine Aminotransferase and Gamma-Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis
- Source :
- Hepatology (Baltimore, Md.), vol 73, iss 3
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Background and aimsPredictive, noninvasive tools are needed to monitor key features of nonalcoholic fatty liver disease (NAFLD) in children that relate to improvement in liver histology. The purpose of this study was to evaluate the relationship between liver chemistries and liver histology using data from the CyNCh (Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children) clinical trial.Approach and resultsThis study included 146 children. Improvement in liver histology, defined as decrease in nonalcoholic fatty liver disease (NAFLD) Activity Score ≥2 points without worsening of fibrosis, occurred in 43 participants (30%). There were 46 participants with borderline zone 1 nonalcoholic steatohepatitis (NASH) at baseline, with resolution in 28% (12 of 46). Multivariate models were constructed using baseline and change in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at 52weeks, for improvement in (1) liver histology primary outcome, (2) borderline zone 1 NASH, and (3) fibrosis. For improvement in histology, the model (P&nbsp
- Subjects :
- Male
Adolescent
Cysteamine
Clinical Trials and Supportive Activities
Chronic Liver Disease and Cirrhosis
Clinical Sciences
Immunology
Medical Biochemistry and Metabolomics
Oral and gastrointestinal
Hepatitis
Predictive Value of Tests
Non-alcoholic Fatty Liver Disease
Clinical Research
Humans
Aspartate Aminotransferases
Child
Gastroenterology & Hepatology
Liver Disease
Remission Induction
Alanine Transaminase
gamma-Glutamyltransferase
Prognosis
Treatment Outcome
Good Health and Well Being
Liver
Delayed-Action Preparations
Nonalcoholic Steatohepatitis Clinical Research Network
Female
Digestive Diseases
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Hepatology (Baltimore, Md.), vol 73, iss 3
- Accession number :
- edsair.od.......325..bde0b7e7ec9223e24116975bdfc2b3fb