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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Source :
- Nature genetics, vol 53, iss 1
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
- Subjects :
- Male
Urologic Diseases
Aging
Quantitative Trait Loci
Medical and Health Sciences
Risk Factors
Clinical Research
Odds Ratio
Genetics
Humans
2.1 Biological and endogenous factors
Neoplasm Invasiveness
Genetic Predisposition to Disease
Aetiology
Cancer
Prevention
Prostate Cancer
Racial Groups
Human Genome
Prostatic Neoplasms
Molecular Sequence Annotation
Genomics
Middle Aged
Biological Sciences
Phenotype
Good Health and Well Being
Genetic Loci
Software
Genome-Wide Association Study
Statistical Distributions
Developmental Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature genetics, vol 53, iss 1
- Accession number :
- edsair.od.......325..a3a89068ea1db700c9bd58cef62d68f7