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Estimated glomerular filtration rate changes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
- Source :
- Cancer, vol 121, iss 21
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- BackgroundChronic use of tyrosine kinase inhibitors (TKIs) may lead to previously unrecognized adverse events. This study evaluated the incidence of acute kidney injury (AKI) and chronic kidney disease (CKD) in chronic-phase (CP) chronic myeloid leukemia (CML) patients treated with imatinib, dasatinib, and nilotinib.MethodsFour hundred sixty-eight newly diagnosed CP CML patients treated with TKIs were analyzed. The molecular and cytogenetic response data, creatinine, and glomerular filtration rate (GFR) were followed from the start of therapy to the last follow-up (median, 52 months). GFR was estimated with the Modification of Diet in Renal Disease equation.ResultsNineteen patients (4%) had TKI-associated AKI. Imatinib was associated with a higher incidence of AKI in comparison with dasatinib and nilotinib (P = .014). Fifty-eight patients (14%) developed CKD while they were receiving a TKI; 49 of these patients (84%) did so while they were being treated with imatinib (P
- Subjects :
- Adult
Male
Kidney Disease
Adolescent
Oncology and Carcinogenesis
Dasatinib
Renal and urogenital
Kidney
Dose-Response Relationship
Young Adult
tyrosine kinase inhibitor
Rare Diseases
chronic myeloid leukemia
Clinical Research
80 and over
Humans
Renal Insufficiency
Oncology & Carcinogenesis
Chronic
Protein Kinase Inhibitors
nilotinib
Retrospective Studies
Aged
Cancer
Leukemia
Incidence
Evaluation of treatments and therapeutic interventions
glomerular filtration rate changes
Hematology
Middle Aged
Protein-Tyrosine Kinases
Acute Kidney Injury
Pyrimidines
Treatment Outcome
imatinib
Creatinine
6.1 Pharmaceuticals
Imatinib Mesylate
kidney injury
outcome
Public Health and Health Services
Female
BCR-ABL Positive
Drug
Glomerular Filtration Rate
Follow-Up Studies
Myelogenous
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cancer, vol 121, iss 21
- Accession number :
- edsair.od.......325..a19632f0b9923ba4a8af1a06763902a4