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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels
- Source :
- Human molecular genetics, vol 26, iss 9
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P
- Subjects :
- Adult
Male
HDL
Lipoproteins
Quantitative Trait Loci
Medical and Health Sciences
Linkage Disequilibrium
White People
LDL
Gene Frequency
Asian People
Ethnicity
Genetics
Humans
2.1 Biological and endogenous factors
Polymorphism
Aetiology
Triglycerides
Alleles
Genetic Association Studies
Metabolic and endocrine
Genetics & Heredity
Human Genome
Single Nucleotide
Middle Aged
Biological Sciences
Atherosclerosis
Lipids
Cholesterol
Female
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Human molecular genetics, vol 26, iss 9
- Accession number :
- edsair.od.......325..964fb1bdf2c1d313e3b870db7eb36c73