Neuroscience: Identification and functional characterization of brainstem cannabinoid CB2 receptors

Authors :: Van Sickle, MD
Duncan, M
Kingsley, PJ
Mouihate, A
Urbani, P
Mackie, K
Stella, N
Makriyannis, A
Piomelli, D
Davison, JS
Marnett, LJ
Di Marzo, V
Pittman, QJ
Patel, KD
Sharkey, KA
Source :: Van Sickle, MD; Duncan, M; Kingsley, PJ; Mouihate, A; Urbani, P; Mackie, K; et al.(2005). Neuroscience: Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science, 310(5746), 329-332. doi: 10.1126/science.1115740. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88q0m818
Publication Year :: 2005
Publisher :: eScholarship, University of California, 2005.
Abstract: The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial We report the expression of CB 2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.

Subjects :: nervous system
musculoskeletal, neural, and ocular physiology
lipids (amino acids, peptides, and proteins)
psychological phenomena and processes

Language :: English
Database :: OpenAIRE
Journal :: Van Sickle, MD; Duncan, M; Kingsley, PJ; Mouihate, A; Urbani, P; Mackie, K; et al.(2005). Neuroscience: Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science, 310(5746), 329-332. doi: 10.1126/science.1115740. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88q0m818
Accession number :: edsair.od.......325..794ec0f27526f8406908859f4ab24055
Full Text :: https://doi.org/10.1126/science.1115740.

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