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Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF
- Source :
- Huffman, JE; De Vries, PS; Morrison, AC; Sabater-Lleal, M; Kacprowski, T; Auer, PL; et al.(2015). Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood, 126(11), e19-e29. doi: 10.1182/blood-2015-02-624551. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8v59n2sf
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- © 2015, American Society of Hematology. All rights reserved. Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Huffman, JE; De Vries, PS; Morrison, AC; Sabater-Lleal, M; Kacprowski, T; Auer, PL; et al.(2015). Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood, 126(11), e19-e29. doi: 10.1182/blood-2015-02-624551. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8v59n2sf
- Accession number :
- edsair.od.......325..7357bdeda572131e981a8edf5745f1dc