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Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report
- Source :
- Neurosurgery, vol 80, iss 4
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."
- Subjects :
- Clinical Trials as Topic
Registry
Comparative Effectiveness Research
Biomedical Research
Neurology & Neurosurgery
Effectiveness research
Clinical Trials and Supportive Activities
Clinical Sciences
Neurosurgery
Academies and Institutes
Neurosciences
Guidelines as Topic
Neurosurgical Procedures
Clinical trials
Research Design
Randomized controlled trial
Clinical Research
Humans
Equipoise
Workshop Participants
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Neurosurgery, vol 80, iss 4
- Accession number :
- edsair.od.......325..67671d9c45b5f977592cca797081a657