High yield and high specific activity synthesis of [18F] fallypride in a batch microfluidic reactor for micro-PET imaging

Authors :: Javed, MR
Chen, S
Lei, J
Collins, J
Sergeev, M
Kim, HK
Kim, CJ
Van Dam, RM
Keng, PY
Source :: Javed, MR; Chen, S; Lei, J; Collins, J; Sergeev, M; Kim, HK; et al.(2014). High yield and high specific activity synthesis of [18F] fallypride in a batch microfluidic reactor for micro-PET imaging. Chemical Communications, 50(10), 1192-1194. doi: 10.1039/c3cc47616b. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4zp2t8t9
Publication Year :: 2014
Publisher :: eScholarship, University of California, 2014.
Abstract: [18F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol-1 (20 Ci μmol-1) (n = 4). Specific activity was ∼2-fold higher than [18F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip. © 2014 The Royal Society of Chemistry.

Language :: English
Database :: OpenAIRE
Journal :: Javed, MR; Chen, S; Lei, J; Collins, J; Sergeev, M; Kim, HK; et al.(2014). High yield and high specific activity synthesis of [18F] fallypride in a batch microfluidic reactor for micro-PET imaging. Chemical Communications, 50(10), 1192-1194. doi: 10.1039/c3cc47616b. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4zp2t8t9
Accession number :: edsair.od.......325..6020ec8db50572ca6fc84a86e6512b7d

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