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Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation

Authors :
Pontis, S
Ribeiro, A
Sasso, O
Piomelli, D
Source :
Pontis, S; Ribeiro, A; Sasso, O; & Piomelli, D. (2015). Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation. Critical Reviews in Biochemistry and Molecular Biology, 1-8. doi: 10.3109/10409238.2015.1092944. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7c82j1t6
Publication Year :
2015
Publisher :
eScholarship, University of California, 2015.

Abstract

© 2015 Taylor & Francis. Macrophages are multi-faceted phagocytic effector cells that derive from circulating monocytes and undergo differentiation in target tissues to regulate key aspects of the inflammatory process. Macrophages produce and degrade a variety of lipid mediators that stimulate or suppress pain and inflammation. Among the analgesic and anti-inflammatory lipids released from these cells are the fatty acid ethanolamides (FAEs), which produce their effects by engaging nuclear peroxisome proliferator activated receptor-α (PPAR-α). Two members of this lipid family, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), have recently emerged as important intrinsic regulators of nociception and inflammation. These substances are released from the membrane precursor, N-acylphosphatidylethanolamine (NAPE), by the action of a NAPE-specific phospholipase D (NAPE-PLD), and in macrophage are primarily deactivated by the lysosomal cysteine amidase, N-acylethanolamine acid amidase (NAAA). NAPE-PLD and NAAA regulate FAE levels, exerting a tight control over the ability of these lipid mediators to recruit PPAR-α and attenuate the inflammatory response. This review summarizes recent findings on the contribution of the FAE-PPAR-α signaling complex in inflammation, and on NAAA inhibition as a novel mechanistic approach to treat chronic inflammatory disorders.

Details

Language :
English
Database :
OpenAIRE
Journal :
Pontis, S; Ribeiro, A; Sasso, O; & Piomelli, D. (2015). Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation. Critical Reviews in Biochemistry and Molecular Biology, 1-8. doi: 10.3109/10409238.2015.1092944. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7c82j1t6
Accession number :
edsair.od.......325..2063bc3bdd6b4b91c06951de69a2897f
Full Text :
https://doi.org/10.3109/10409238.2015.1092944.