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Survival benefits associated with surgery for advanced non–small cell lung cancer

Authors :
David, EA
Andersen, SW
Beckett, LA
Melnikow, J
Clark, JM
Brown, LM
Cooke, DT
Kelly, K
Canter, RJ
Source :
David, EA; Andersen, SW; Beckett, LA; Melnikow, J; Clark, JM; Brown, LM; et al.(2018). Survival benefits associated with surgery for advanced non–small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery. doi: 10.1016/j.jtcvs.2018.10.140. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5xg9h3qp
Publication Year :
2018
Publisher :
eScholarship, University of California, 2018.

Abstract

© 2018 Objective: Overall survival (OS) for advanced stage (IIIA-IV) non–small cell lung cancer (NSCLC) is highly variable, and retrospective data show a survival advantage for patients receiving therapeutic intent pulmonary resection. We hypothesized that this variability in OS can be modeled separately by stage to allow a personalized estimate of OS. Methods: In a cohort of patients with advanced-stage NSCLC from the National Cancer Database, we assessed the accuracy of Surgical Selection Score (SSS) to predict OS using Cox proportional hazards models and determined by stage the effect of surgery on survival among people with similarly high levels of SSS. Results: In total, 300,572 patients were identified; 18,701 (6%) had surgery. The SSS was a strong predictor of OS (C-index, 0.89; 95% confidence interval [CI], 0.89-0.90). We observed significantly greater OS (P

Details

Language :
English
Database :
OpenAIRE
Journal :
David, EA; Andersen, SW; Beckett, LA; Melnikow, J; Clark, JM; Brown, LM; et al.(2018). Survival benefits associated with surgery for advanced non–small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery. doi: 10.1016/j.jtcvs.2018.10.140. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5xg9h3qp
Accession number :
edsair.od.......325..1e896776cca7ba295b9e6394ea3aea82