Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

Authors :: Homburger, J. R.
Green, E. M.
Caleshu, C.
Sunitha, M. S.
Taylor, R. E.
Ruppel, K. M.
Metpally, R. P. R.
Colan, S. D.
Michels, M.
Day, S. M.
Olivotto, I.
Bustamante, C. D.
Dewey, F. E.
C. Y., Ho
Spudich, J. A.
Ashley, E. A.
Publication Year :: 2016

Subjects :: macromolecular substances
Genetic burden
Hypertrophic cardiomyopathy
Myosin
Rare disease genetics
Cardiac Myosins
Cardiomegaly
Death, Sudden, Cardiac
Female
Genetic Diseases, Inborn
Heart Failure
Humans
Male
Myosin Heavy Chains
Structure-Activity Relationship
Databases, Genetic
Genetic Variation
Models, Molecular

Tools