Developing Renal Clearable Nanoparticles for the Treatment of Renal Cell Carcinoma

Renal Cell Carcinoma (RCC) is the most common form of kidney cancer and has proven itself to be difficult to treat with conventional chemotherapy and radiotherapy. Nanoparticles (NPs), however, have been shown to significantly improve the efficacy of chemotherapy for RCC in recent years. A primary issue with using NPs is the safety concerns and potential side effects such as their permanent accumulation in major organs. To address this issue, the focus of my PhD study is the synthesis of novel non-toxic NPs that can be cleared by the kidneys or biocompatible/biodegradable NPs that can be used to deliver drugs/inhibitors to combat RCC. In this study, four type of renal clearable carbon dots and two types of biocompatible NPs have been developed. Among all these NPs, renal clearable NP called Sucrose Carbon Dots (Suc CDs) were created to carry hydrophilic drugs and Polymeric Micelles (P.M) were employed to carry hydrophobic drugs. Suc CDs ware developed with size