DAFNE: improved quality of life with intensified treatment is counter-intuitive to many clinicians

Many of the early rapid responses to the DAFNE trial paper (1) [see bmj.com] claimed that improved quality of life (QoL) resulting from flexible intensified insulin treatment was well established prior to the DAFNE trial (Ullman, 5th Oct; Black, 6th Oct; Chaufan, 12th Oct). However, the only evidence cited was anecdotal.