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Evidence for a 'metabolically inactive' inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T
- Source :
- Journal of Cerebral Blood Flow and Metabolism, Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2016, 36 (9), pp.1513-1518. ⟨10.1177/0271678X16657095⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; With the increased spectral resolution made possible at high fields, a second, smaller inorganic phosphate resonance can be resolved on $^{31}$P magnetic resonance spectra in the rat brain. Saturation transfer was used to estimate de $novo$ adenosine triphosphate synthesis reaction rate. While the main inorganic phosphate pool is used by adenosine triphos-phate synthase, the second pool is inactive for this reaction. Accounting for this new pool may not only help us understand $^{31}$P magnetic resonance spectroscopy metabolic profiles better but also better quantify adenosine triphos-phate synthesis.
Details
- Language :
- English
- ISSN :
- 0271678X and 15597016
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow and Metabolism, Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2016, 36 (9), pp.1513-1518. ⟨10.1177/0271678X16657095⟩
- Accession number :
- edsair.od.......212..bd581562de8fd23a9b5324c6888bf62a