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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Authors :
Zhang, Haoyu Ahearn, Thomas U Lecarpentier, Julie Barnes, Daniel Beesley, Jonathan Qi, Guanghao Jiang, Xia O'Mara, Tracy A Zhao, Ni Bolla, Manjeet K Dunning, Alison M Dennis, Joe Wang, Qin Ful, Zumuruda Abu Aittomäki, Kristiina Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Aronson, Kristan J Arun, Banu K Auer, Paul L Azzollini, Jacopo Barrowdale, Daniel Becher, Heiko Beckmann, Matthias W Behrens, Sabine Benitez, Javier Bermisheva, Marina Bialkowska, Katarzyna Blanco, Ana Blomqvist, Carl Bogdanova, Natalia V Bojesen, Stig E Bonanni, Bernardo Bondavalli, Davide Borg, Ake Brauch, Hiltrud Brenner, Hermann Briceno, Ignacio Broeks, Annegien Brucker, Sara Y Brüning, Thomas Burwinkel, Barbara Buys, Saundra S Byers, Helen Caldés, Trinidad Caligo, Maria A Calvello, Mariarosaria Campa, Daniele Castelao, Jose E Chang-Claude, Jenny Chanock, Stephen J Christiaens, Melissa Christiansen, Hans Chung, Wendy K Claes, Kathleen BM Clarke, Christine L Cornelissen, Sten Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Devilee, Peter Diez, Orland Domchek, Susan M Dörk, Thilo Dwek, Miriam Eccles, Diana M Ekici, Arif B Evans, D Gareth Fasching, Peter A Figueroa, Jonine Foretova, Lenka Fostira, Florentia Friedman, Eitan Frost, Debra Gago-Dominguez, Manuela Gapstur, Susan M Garber, Judy García-Sáenz, José A Gaudet, Mia M Gayther, Simon A Giles, Graham G Godwin, Andrew K Goldberg, Mark S Goldgar, David E González-Neira, Anna Greene, Mark H Gronwald, Jacek Guénel, Pascal Häberle, Lothar Hahnen, Eric Haiman, Christopher A Hake, Christopher R Hall, Per Hamann, Ute Harkness, Elaine F Heemskerk-Gerritsen, Bernadette AM Hillemanns, Peter Hogervorst, Frans BL Holleczek, Bernd Hollestelle, Antoinette Hooning, Maartje J Hoover, Robert N Hopper, John L Howell, Anthony Huebner, Hanna Hulick, Peter J Imyanitov, Evgeny N kConFab Investigators ABCTB Investigators Isaacs, Claudine Izatt, Louise Jager, Agnes Jakimovska, Milena Jakubowska, Anna James, Paul Janavicius, Ramunas Janni, Wolfgang John, Esther M Jones, Michael E Jung, Audrey Kaaks, Rudolf Kapoor, Pooja Middha Karlan, Beth Y Keeman, Renske Khan, Sofia Khusnutdinova, Elza Kitahara, Cari M Ko, Yon-Dschun Konstantopoulou, Irene Koppert, Linetta B Koutros, Stella Kristensen, Vessela N Laenkholm, Anne-Vibeke Lambrechts, Diether Larsson, Susanna C Laurent-Puig, Pierre Lazaro, Conxi Lazarova, Emilija Lejbkowicz, Flavio Leslie, Goska Lesueur, Fabienne Lindblom, Annika Lissowska, Jolanta Lo, Wing-Yee Loud, Jennifer T Lubinski, Jan Lukomska, Alicja MacInnis, Robert J Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Matricardi, Laura McGuffog, Lesley McLean, Catriona Mebirouk, Noura Meindl, Alfons Menon, Usha Miller, Austin Mingazheva, Elvira Montagna, Marco Mulligan, Anna Marie Mulot, Claire Muranen, Taru A Nathanson, Katherine L Neuhausen, Susan L Nevanlinna, Heli Neven, Patrick Newman, William G Nielsen, Finn C Nikitina-Zake, Liene Nodora, Jesse Offit, Kenneth Olah, Edith Olopade, Olufunmilayo I Olsson, Håkan Orr, Nick Papi, Laura Papp, Janos Park-Simon, Tjoung-Won Parsons, Michael T Peissel, Bernard Peixoto, Ana Peshkin, Beth Peterlongo, Paolo Peto, Julian Phillips, Kelly-Anne Piedmonte, Marion Plaseska-Karanfilska, Dijana Prajzendanc, Karolina Prentice, Ross Prokofyeva, Darya Rack, Brigitte Radice, Paolo Ramus, Susan J Rantala, Johanna Rashid, Muhammad U Rennert, Gad Rennert, Hedy S Risch, Harvey A Romero, Atocha Rookus, Matti A Rübner, Matthias Rüdiger, Thomas Saloustros, Emmanouil Sampson, Sarah Sandler, Dale P Sawyer, Elinor J Scheuner, Maren T Schmutzler, Rita K Schneeweiss, Andreas Schoemaker, Minouk J Schöttker, Ben Schürmann, Peter Senter, Leigha Sharma, Priyanka Sherman, Mark E Shu, Xiao-Ou Singer, Christian F Smichkoska, Snezhana Soucy, Penny Southey, Melissa C Spinelli, John J Stone, Jennifer Stoppa-Lyonnet, Dominique EMBRACE Study GEMO Study Collaborators Swerdlow, Anthony J Szabo, Csilla I Tamimi, Rulla M Tapper, William J Taylor, Jack A Teixeira, Manuel R Terry, MaryBeth Thomassen, Mads Thull, Darcy L Tischkowitz, Marc Toland, Amanda E Tollenaar, Rob AEM Tomlinson, Ian Torres, Diana Troester, Melissa A Truong, Thérèse Tung, Nadine Untch, Michael Vachon, Celine M van den Ouweland, Ans MW van der Kolk, Lizet E van Veen, Elke M vanRensburg, Elizabeth J Vega, Ana Wappenschmidt, Barbara Weinberg, Clarice R Weitzel, Jeffrey N Wildiers, Hans Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Yannoukakos, Drakoulis Zheng, Wei Zorn, Kristin K Milne, Roger L Kraft, Peter Simard, Jacques Pharoah, Paul DP Michailidou, Kyriaki Antoniou, Antonis C Schmidt, Marjanka K Chenevix-Trench, Georgia Easton, Douglas F Chatterjee, Nilanjan García-Closas, Montserrat Barnes, Daniel [0000-0002-3781-7570] O'Mara, Tracy A [0000-0002-5436-3232] Dunning, Alison M [0000-0001-6651-7166] Dennis, Joe [0000-0003-4591-1214] Andrulis, Irene L [0000-0002-4226-6435] Arndt, Volker [0000-0001-9320-8684] Azzollini, Jacopo [0000-0002-9364-9778] Bojesen, Stig E [0000-0002-4061-4133] Bonanni, Bernardo [0000-0003-3589-2128] Brauch, Hiltrud [0000-0001-7531-2736] Caldés, Trinidad [0000-0002-1038-5392] Calvello, Mariarosaria [0000-0003-2113-8503] Chanock, Stephen J [0000-0002-2324-3393] Claes, Kathleen BM [0000-0003-0841-7372] Devilee, Peter [0000-0002-8023-2009] Dörk, Thilo [0000-0002-9458-0282] Dwek, Miriam [0000-0001-7184-2932] Ekici, Arif B [0000-0001-6099-7066] Fasching, Peter A [0000-0003-4885-8471] García-Sáenz, José A [0000-0001-6880-0301] Gayther, Simon A [0000-0001-7937-5443] Giles, Graham G [0000-0003-4946-9099] Greene, Mark H [0000-0003-1852-9239] Guénel, Pascal [0000-0002-8359-518X] Harkness, Elaine F [0000-0001-6625-7739] Heemskerk-Gerritsen, Bernadette AM [0000-0002-9724-6693] Hollestelle, Antoinette [0000-0003-1166-1966] Huebner, Hanna [0000-0001-6889-1493] Hulick, Peter J [0000-0001-8397-4078] Jakimovska, Milena [0000-0002-1506-0669] Jakubowska, Anna [0000-0002-5650-0501] James, Paul [0000-0002-4361-4657] Jones, Michael E [0000-0001-7479-3451] Kapoor, Pooja Middha [0000-0001-5503-8215] Keeman, Renske [0000-0002-5452-9933] Konstantopoulou, Irene [0000-0002-0470-0309] Larsson, Susanna C [0000-0003-0118-0341] Laurent-Puig, Pierre [0000-0001-8475-5459] Leslie, Goska [0000-0001-5756-6222] Lesueur, Fabienne [0000-0001-7404-4549] Lissowska, Jolanta [0000-0003-2695-5799] Matricardi, Laura [0000-0002-0241-1810] McLean, Catriona [0000-0002-0302-5727] Menon, Usha [0000-0003-3708-1732] Miller, Austin [0000-0001-9739-8462] Muranen, Taru A [0000-0002-5895-1808] Nathanson, Katherine L [0000-0002-6740-0901] Nevanlinna, Heli [0000-0002-0916-2976] Newman, William G [0000-0002-6382-4678] Olopade, Olufunmilayo I [0000-0002-9936-1599] Orr, Nick [0000-0003-2866-942X] Parsons, Michael T [0000-0003-3242-8477] Peshkin, Beth [0000-0002-2997-4701] Peterlongo, Paolo [0000-0001-6951-6855] Peto, Julian [0000-0002-1685-8912] Plaseska-Karanfilska, Dijana [0000-0001-8877-2416] Radice, Paolo [0000-0001-6298-4111] Rennert, Gad [0000-0002-8512-068X] Romero, Atocha [0000-0002-1634-7397] Saloustros, Emmanouil [0000-0002-0485-0120] Stone, Jennifer [0000-0001-5077-0124] Teixeira, Manuel R [0000-0002-4896-5982] Toland, Amanda E [0000-0002-0271-1792] Tomlinson, Ian [0000-0003-3037-1470] van Veen, Elke M [0000-0001-8618-2332] vanRensburg, Elizabeth J [0000-0003-2077-230X] Weitzel, Jeffrey N [0000-0001-6714-092X] Winqvist, Robert [0000-0003-0932-9104] Wolk, Alicja [0000-0001-7387-6845] Yannoukakos, Drakoulis [0000-0001-7509-3510] Zheng, Wei [0000-0003-1226-070X] Milne, Roger L [0000-0001-5764-7268] Kraft, Peter [0000-0002-4472-8103] Simard, Jacques [0000-0001-6906-3390] Pharoah, Paul DP [0000-0001-8494-732X] Michailidou, Kyriaki [0000-0001-7065-1237] Schmidt, Marjanka K [0000-0002-2228-429X] Easton, Douglas F [0000-0003-2444-3247] Chatterjee, Nilanjan [0000-0002-9060-008X] García-Closas, Montserrat [0000-0003-1033-2650] Apollo - University of Cambridge Repository
Publication Year :
2020
Publisher :
Springer Science and Business Media LLC, 2020.
Abstract
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P
Details
Database :
OpenAIRE
Accession number :
edsair.od.......109..883b4cc2606ff0825d0d89e0040c0014