Histamine in hemorrhagic shock - A new approach with microdialysis

Microdialysis is a new approach for monitoring after hemorrhagic shock. The advantage of microdialysis is the local measurement of microcirculation and local changes of mediators. Until now this was mostly used in neuromonitoring. In this experiment we were focussed on the local changes of histamine in the liver after hemorrhagic shock by female pigs. Histamine is a vasoactive mediator which is well described in septic shock. The role of histamine after hemorrhagic shock is rarely known. Especially changes of histamine in the liver after shock is from our knowledge not clear. We could show, that after a short peak by placing the probes in the liver histamine increased in shock and we could further see, that we get two different reactions of histamine in the liver in shock depending on the position of the probes. Central placed probes do not show a relevant increase of histamine during hemorrhagic shock. If probes are placed in periphery regions of the liver microdialysis shows a significant increase of histamine by those animals, which die in an early phase after shock. Surviving animals do not get such an increase of histamine. In our experiment histamine had a prognostic value by peripheral placed probes in the liver after hemorrhagic shock.