Blunted rise in platelet count in critically ill patients is associated with worse outcome

Objective: To test the hypothesis that a low rate of change of platelet counts (PCs) after admission to the intensive care unit (ICU) is associated with mortality. Low PCs are known to be associated with disease severity in critically ill patients, but the relevance of time-dependent changes of PCs has not been investigated. Design: Retrospective study. Setting: A 12-bed surgical ICU of a university hospital. Patients: All adult patients admitted to the ICU for at least 4 days during a 7-yr period. Interventions: At admission, Acute Physiology anti Chronic Health Evaluation scores were calculated. PCs and leukocyte counts were analyzed from admission to day 10. The daily rise of the PCs (Delta PC/Deltat) from day 2 to day 10 was calculated. Rates for 30-day mortality as well as hospital mortality were determined. Measurements and Main Results: A total of 1415 admissions were studied. Median PCs (interquartile range) initially decreased and subsequently increased, with a higher PC in 1203 survivors than in 212 nonsurvivors from day 2 onward (302 [range, 181-438].10(3)/mm(3)/day vs. 129 [range, 62-228].10(3)/mm(3) at day 10; p