Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: A F-18-fluorodeoxyglucose positron emission tomography study

To investigate the pathophysiology of fatigue in MS, we assessed cerebral glucose metabolism (CMRGlu) in 47 MS patients using PET and F-18-fluorodeoxyglucose. Applying the Fatigue Severity Scale (FSS), we first compared MS patients with severe fatigue (MS-FAT, n = 19, FSS > 4.9) and MS patients without fatigue (MS-NOF, n = 16, FSS