Back to Search Start Over

Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models—Introduction of the “RatOx” Oxygenator and Preliminary In Vitro Results

Authors :
Jansen, Lasse J. Strudthoff
Jannis Focke
Felix Hesselmann
Andreas Kaesler
Ana Martins Costa
Peter C. Schlanstein
Thomas Schmitz-Rode
Ulrich Steinseifer
Niklas B. Steuer
Bettina Wiegmann
Jutta Arens
Sebastian V.
Source :
Micromachines; Volume 14; Issue 4; Pages: 800
Publication Year :
2023
Publisher :
Multidisciplinary Digital Publishing Institute, 2023.

Abstract

The overall survival rate of extracorporeal life support (ECLS) remains at 60%. Research and development has been slow, in part due to the lack of sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) and presents preliminary in vitro classification tests. The RatOx has an adaptable fiber module size for various rodent models. Gas transfer performances over the fiber module for different blood flows and fiber module sizes were tested according to DIN EN ISO 7199. At the maximum possible amount of effective fiber surface area and a blood flow of 100 mL/min, the oxygenator performance was tested to a maximum of 6.27 mL O2/min and 8.2 mL CO2/min, respectively. The priming volume for the largest fiber module is 5.4 mL, while the smallest possible configuration with a single fiber mat layer has a priming volume of 1.1 mL. The novel RatOx ECLS system has been evaluated in vitro and has demonstrated a high degree of compliance with all pre-defined functional criteria for rodent-sized animal models. We intend for the RatOx to become a standard testing platform for scientific studies on ECLS therapy and technology.

Details

Language :
English
ISSN :
2072666X
Database :
OpenAIRE
Journal :
Micromachines; Volume 14; Issue 4; Pages: 800
Accession number :
edsair.multidiscipl..89694dd8c912ebd1825dd9a40ca91be3
Full Text :
https://doi.org/10.3390/mi14040800