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Phenotype and Reactivity of Lymphocytes Expanded from Benign Prostate Hyperplasic Tissues and Prostate Cancer

Authors :
Viganó, Ritaparna Ahmed
Leyder Elena Lozano
Amandine Anastasio
Sebastien Lofek
Beatris Mastelic-Gavillet
Blanca Navarro Rodrigo
Sylvain Nguyen
Florence Dartiguenave
Sonia-Cristina Rodrigues-Dias
Valérie Cesson
Massimo Valério
Beat Roth
Lana Elias Kandalaft
Irina Redchenko
Adrian Vivian Sinton Hill
Alexandre Harari
Pedro Romero
Laurent Derré
Selena
Source :
Cancers; Volume 15; Issue 12; Pages: 3114
Publication Year :
2023
Publisher :
Multidisciplinary Digital Publishing Institute, 2023.

Abstract

Benign prostate hyperplasia (BPH) is a frequent condition in aging men, which affects life quality, causing principally lower urinary tract symptoms. Epidemiologic studies suggest that BPH may raise the risk of developing prostate cancer (PCa), most likely promoting a chronic inflammatory environment. Studies aiming at elucidating the link and risk factors that connect BPH and PCa are urgently needed to develop prevention strategies. The BPH microenvironment, similar to the PCa one, increases immune infiltration of the prostate, but, in contrast to PCa, immunosuppression may not be established yet. In this study, we found that prostate-infiltrating lymphocytes (PILs) expanded from hyperplastic prostate tissue recognized tumor-associated antigens (TAA) and autologous tissue, regardless of the presence of tumor cells. PILs expanded from BPH samples of patients with PCa, however, seem to respond more strongly to autologous tissue. Phenotypic characterization of the infiltrating PILs revealed a trend towards better expanding CD4+ T cells in infiltrates derived from PCa, but no significant differences were found. These findings suggest that T cell tolerance is compromised in BPH-affected prostates, likely due to qualitative or quantitative alterations of the antigenic landscape. Our data support the hypothesis that BPH increases the risk of PCa and may pave the way for new personalized preventive vaccine strategies for these patients.

Details

Language :
English
ISSN :
20726694
Database :
OpenAIRE
Journal :
Cancers; Volume 15; Issue 12; Pages: 3114
Accession number :
edsair.multidiscipl..6ac0381b595bfe0e7502c504412d83d7
Full Text :
https://doi.org/10.3390/cancers15123114