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The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

Authors :
Balcerek, Anja Borgmann-Staudt
Simon Michael
Greta Sommerhaeuser
Marta-Julia Fernández-González
Lucía Alacán Friedrich
Stephanie Klco-Brosius
Tomas Kepak
Jarmila Kruseova
Gisela Michel
Anna Panasiuk
Sandrin Schmidt
Laura Lotz
Magdalena
Source :
Current Oncology; Volume 29; Issue 8; Pages: 5748-5762
Publication Year :
2022
Publisher :
Multidisciplinary Digital Publishing Institute, 2022.

Abstract

CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615–5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401–4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.

Details

Language :
English
ISSN :
17187729
Database :
OpenAIRE
Journal :
Current Oncology; Volume 29; Issue 8; Pages: 5748-5762
Accession number :
edsair.multidiscipl..69f859e744914c5fd045f0664e14ab64
Full Text :
https://doi.org/10.3390/curroncol29080453