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BIOACTIVE CONSTITUENTS FROM THE LEAVES OF MELASTOMA MALABATHRICUM L
- Source :
- Jurnal Ilmiah Farmasi; Vol 5, No 1 (2008)
- Publication Year :
- 2009
- Publisher :
- Jurnal Ilmiah Farmasi, 2009.
-
Abstract
- Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.(Melastomataceae) have been investigated. The n-hexane extract yielded -amyrin, patriscabatrineand auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gavequercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts andisolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidantassay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition morethan 90% in the FTC method. Quercetin was found to be the most active as radical scavenger inDPPH method with IC50 of 0.69 M. -Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPAmouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastomamalabathricum, Terpenoid
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Jurnal Ilmiah Farmasi
- Accession number :
- edsair.journalporta..f43935b2abb88ab0ea5602e997284874