高異型度漿液性癌における、卵管前癌病変のp53, CD44v9, Ki-67の免疫組織化学的発現態度

Pelvic high-grade serous carcinoma (HGSC) has been postulated to arise via a stepwise accumulation of (epi)genetic alterations from normal epithelium to secretory cell outgrowth (SCOUT), p53 signature, and serous tubal intraepithelial carcinoma (STIC) to invasive HGSC. The aim of this study is to investigate alterations in p53 and CD44v9 expression and the status of Ki-67 labeling index in a series of fallopian tube lesions of HGSC patients. A total of 45 specimens were analyzed in 16 patients with HGSC, and their lesions were categorized as follows: morphologically normal fallopian tube epithelium (FTE, n=6 samples), SCOUT (n=5), p53 signature (n=4), dormant STIC (n=8), active STIC (n=6), and HGSC (n=16). Morphologic features and immunohistochemical expression patterns of the p53 protein, CD44v9 protein, and Ki-67 antigen were blindly evaluated by 2 pathologists. Increased nuclear p53 protein accumulation was observed in p53 signature, dormant STIC, active STIC and HGSC compared with normal FTE and SCOUT (P
博士（医学）・甲第830号・令和4年3月15日
Copyright © 2021 by the International Society of Gynecological Pathologists.
This article has been accepted for publication in International journal of gynecological pathology, 2021 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1097/PGP.0000000000000738.
発行元が定める登録猶予期間終了の後、本文を登録予定（2022.09）