CLS-PET: a high-resolution multi-purpose portable small-animal PET with DOI and TOF capability

Once a high-resolution PET detector with both depth-of-interaction and time-of-flight capabilities is established, it will be applied to various-type PET systems using a software-based coincidence method. Toward this goal, we have developed a crosshair light-sharing (CLS) detector. In this work, as the first development of a practical system based on the CLS detector, we realized a high-resolution portable small animal PET with a long axial field-of-view (FOV) of 20 cm. The system was composed of 128 CLS detectors. All devices were mounted on a pushcart, and the system was operated on a 100V power supply. The axial FOV was 207 mm, which covered the total-body of a rat. A 22Na ultra-micro hot phantom was used for spatial resolution measurement, and the NEMA NU4 image quality phantom was used for image quality test. The developed CLS-PET system successfully resolved 0.75 mm rods. Subsequently, normal mouse and rat imaging with 18F-NaF and 18F-FDG were demonstrated. For the NaF-PET, mouse and rat total-body images were obtained, and detailed bone structures were clearly imaged. For the mouse FDG-PET, cardiac FDG uptakes were clearly visualized by the CLS-PET system. In conclusion, the CLS-PET system achieved
2021 IEEE NSS/MIC