リングY染色体と考えられた染色体異常を有する無精子症患者の1例

Authors :: Kuroda, Shinnosuke
Yumura, Yasushi
Hamanoue, Haruka
Yasuda, Kengo
Yamanaka, Hiroyuki
Sanjo, Hiroyuki
Takeshima, Teppei
Kobayashi, Masataka
Kato, Yoshitake
Iwasaki, Akira
Noguchi, Kazumi
Source :: 泌尿器科紀要. 60(11):583-586
Publication Year :: 2014
Publisher :: 泌尿器科紀要刊行会, 2014.
Abstract: A 43-year-old man came to our clinic complaining of infertility and semen analysis showed azoospermia. Analysis of chromosomes showed a mosaic 45, XO/46, X, ＋mar1/46, X, ＋mar2 karyotype, and the marker chromosomes were considered to be two kinds of ring Y chromosomes. Y chromosome microdeletion analysis showed partial deletion of Azoospermic Factor (AZF) a, and complete deletion of AZFb and AZFc. The patient gave up having a child because these results indicated that no sperm would be collected even if Testicular Sperm Extraction (TESE) were performed.