19F high senseitivity imaging for in vivo drug dynamics in mice at 7T with 5-FU

The evaluation of drug efficacy and safety for individuals will become more reliable by performing direct dynamical study of drug itself. This is a study towards this purpose using 5-FU in animals. CSI is often used for the metabolite distribution. However, for the compounds with metabolites in wide range of chemical shift, generation of pulse covering sufficient band width is difficult for imaging instrument. One of the best methods for the dynamical study of 19F containing drug, e.g. 5-FU, has been found to be frequency selective imaging [1]. Here, we evaluate fast imaging sequences including FISP and Flash in comparison to FSE at 7T.