The polymorphisms in β3 and β2 adrenergic receptor gene were associated with glucose metabolism in acute and chronic exercise

[Aim] The purpose of this study is to investigate whether the Trp64Arg polymorphism in β3-Adrenergic receptor (β3AR) gene and the Arg16Gly in β2AR were associated with glucose metabolism in aerobic and resistance exercise. [Methods] Thirteen healthy Japanese women (21~22 years old, BMI: 20.2±1.6) were recruited. The subjects performed 4-week aerobic exercise program (rhythmic dance) at 60% of their maximal heart rate for 20 min/day. After 4-weeks interval they performed 4-week resistance exercise program (sit up, back extension, overhead press, squat, twist) for 10 min/day. Before and after intervention 75-g oral glucose tolerance test were performed. [Results] Eight subjects have wild type (Trp64) of β3AR which is the genotype with high lipolysis activity. Other five subjects have Trp64Arg in β3AR or homozygote of Arg16Gly in β2AR they are the genotypes with high glucose metabolism. In the subjects with high lipolysis type the level of Δ30-50 min glucose was significantly higher during the aerobic exercise compare to that in resting (43.4±17.5 vs. -0.5±20.3 mg/dl, p