腹膜透析を模倣した血液浄化モジュールの形状検討と血液系での性能評価

Four types of mini modules with constant membrane surface area and varying length of hollow fiber were constructed as a portable blood purification system mimicking peritoneal dialysis, and their solute removal performances were evaluated in vitro experiments in aqueous and whole blood systems. The ultrafiltration rate and the overall mass transfer-area coefficient were changed just by changing the length of the hollow fiber in the module. The overall mass transfer-area coefficient calculated from the time course of creatinine concentration in whole blood system suggested that the module could be used clinically by scaling up the module by 6 times.