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Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis

Authors :
Manenti, Guglielmo
Altobelli, Simone
Nezzo, Marco
Antonicoli, Marco
Vasili, Erald
Neroni, Luca
Floris, Roberto
Simonetti, Giovanni
Source :
Case Reports in Radiology.
Publication Year :
2013
Publisher :
Hindawi Publishing Corporation, 2013.

Abstract

Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction. The role of magnetic resonance imaging specifically in natalizumab-associated progressive multifocal leukoencephalopathy is strengthening, and it is gaining importance not only as an irreplaceable diagnostic tool but also as a surveillance and risk stratifying tool in treated patients. While other imaging techniques such as computed tomography lack sensitivity and specificity, magnetic resonance performed with morphological and functional sequences offers clinicians the possibility to early identify the stage of the disease and the emergence of an immune reconstitution inflammatory syndrome after natalizumab blood removal plasmapheresis.

Subjects

Subjects :
Article Subject

Details

Language :
English
ISSN :
20906862
Database :
OpenAIRE
Journal :
Case Reports in Radiology
Accession number :
edsair.hindawi.publ..e244de7e92441cdd827a7de23116a083
Full Text :
https://doi.org/10.1155/2013/415873