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Snake Venom L-Amino Acid Oxidases: Trends in Pharmacology and Biochemistry

Authors :
Izidoro, Luiz Fernando M.
Sobrinho, Juliana C.
Mendes, Mirian M.
Costa, Tássia R.
Grabner, Amy N.
Rodrigues, Veridiana M.
da Silva, Saulo L.
Zanchi, Fernando B.
Zuliani, Juliana P.
Fernandes, Carla F. C.
Calderon, Leonardo A.
Stábeli, Rodrigo G.
Soares, Andreimar M.
Source :
BioMed Research International.
Publication Year :
2014
Publisher :
Hindawi Publishing Corporation, 2014.

Abstract

L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.

Subjects

Subjects :
Article Subject
complex mixtures

Details

Language :
English
ISSN :
23146133
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.hindawi.publ..e1441c42bd3dd25ee75cca6f493132a5
Full Text :
https://doi.org/10.1155/2014/196754