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Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta

Authors :
Costa, Fábio Wildson Gurgel
Chaves, Filipe Nobre
Nogueira, Alexandre Simões
Rodrigues Carvalho, Francisco Samuel
Pereira, Karuza Maria Alves
Kurita, Lúcio Mitsuo
Rodrigues, Rodrigo Rodrigues
Fonteles, Cristiane Sá Roriz
Source :
Case Reports in Dentistry.
Publication Year :
2014
Publisher :
Hindawi Publishing Corporation, 2014.

Abstract

Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in this disease. OI is often associated to severe dental problems, such as dentinogenesis imperfecta (DI) and malocclusions. Radiographically, affected teeth may have crowns with bulbous appearance, accentuated constriction in the cementoenamel junction, narrowed roots, large root canals due to defective dentin formation, and taurodontism (enlarged pulp chambers). There is no definitive cure, but bisphosphonate therapy is reported to improve bone quality; however, there is a potential risk of bisphosphonate-related osteonecrosis of the jaw. In this study we report a case of OI in a male pediatric patient with no family history of OI who was receiving ongoing treatment with intravenous perfusion of bisphosphonate and who required dental surgery. In addition, we discussed the clinical and imaging findings and briefly reviewed the literature.

Details

Language :
English
ISSN :
20906447
Database :
OpenAIRE
Journal :
Case Reports in Dentistry
Accession number :
edsair.hindawi.publ..5e4fe378c8777b025b1a6154efc0f314
Full Text :
https://doi.org/10.1155/2014/384292