Back to Search Start Over

A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies

Authors :
Kayano, Hidekazu
Shimada, Tsuneyuki
Wakimoto, Naoki
Nakamura, Yuichi
Bessho, Masami
Yamaguchi, Hiroshi
Sasaki, Atsushi
Shimizu, Michio
Source :
Bone Marrow Research.
Publication Year :
2011
Publisher :
Hindawi Publishing Corporation, 2011.

Abstract

A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cells. Russell bodies were positive for IgM and lambda immunoglobulin light chain. The patient also underwent gastric biopsy, which revealed Helicobacter pylori (HP) infection. Subsequent eradication of the bacteria resulted in improvement of his thrombocytopenia. The clinical course remained uneventful at 15-month follow-up, consistent with monoclonal B-cell lymphocytosis. The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection.

Subjects

Subjects :
Article Subject

Details

Language :
English
ISSN :
20902999
Database :
OpenAIRE
Journal :
Bone Marrow Research
Accession number :
edsair.hindawi.publ..0fdbe239caea7bed2884f90aa35fba44
Full Text :
https://doi.org/10.1155/2011/814372