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Protein-Templated Dynamic Combinatorial Chemistry
- Source :
- European Journal of Organic Chemistry. 2019(22):3581-3590
- Publication Year :
- 2019
- Publisher :
- WILEY-V C H VERLAG GMBH, 2019.
-
Abstract
- Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives. An ever-increasing number of publications report the use of DCC on biologically relevant target proteins. This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents.
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2019
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- European Journal of Organic Chemistry
- Accession number :
- edsair.dris...01423..e00f7a70700b43c1508d2dff73d6d8c2