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DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos
- Source :
- Nature Cell Biology. 2(2):90-95
- Publication Year :
- 2000
-
Abstract
- During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the gamma-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA, We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails.
Details
- Language :
- English
- ISSN :
- 14657392
- Volume :
- 2
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nature Cell Biology
- Accession number :
- edsair.dris...00893..c0cf853038626ce916fc91203c15c809