Cardiopulmonary bypass and hemostasis

In chapter 1, we recalled that intracardiac defects can only be corrected when cardiopulmonary circulation is maintained by extracorporeal criculation and ventilation. To prevent clot formation in this artificial circuit, the socalled cardiopulmonary bypass (CPB), we completely depend on the anticoagulatory properties of heparin. Heparin inhibits the clotting system, which is triggered via the intrinsic pathway by blood-material interaction.... Zie: Summary