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Models of synaptotagmin-1 to trigger Ca2+-dependent vesicle fusion
- Source :
- FEBS Letters. 592(21)
- Publication Year :
- 2018
-
Abstract
- Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide hormones, which are released by vesicle fusion in response to Ca2+-evoking stimuli. Synaptotagmin-1 (Syt1), a Ca2+ sensor, mediates ultrafast exocytosis in neurons and neuroendocrine cells. After vesicle docking, Syt1 has two main groups of binding partners: anionic phospholipids and the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) complex. The molecular mechanisms by which Syt1 triggers vesicle fusion remain controversial. This Review introduces and summarizes six molecular models of Syt1: (a) Syt1 triggers SNARE unclamping by displacing complexin, (b) Syt1 clamps SNARE zippering, (c) Syt1 causes membrane curvature, (d) membrane bridging by Syt1, (e) Syt1 is a vesicle-plasma membrane distance regulator, and (f) Syt1 undergoes circular oligomerization. We discuss important conditions to test Syt1 activity in vitro and attempt to illustrate the possible roles of Syt1.
- Subjects :
- peptide hormone
SNARE
vesicle fusion
complexin
synaptotagmin-1
neurotransmitter
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 592
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.dris...00893..a24232452ed54663688a9e056477fc65