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Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
- Publication Year :
- 2008
-
Abstract
- Objective - Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol- increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. Methods and Results - InAPOE*3Leiden transgenic mice expressing the human CETP transgene, niacin dose-dependently decreased plasma triglycerides (up to -77%, P
- Subjects :
- Time Factors
Messenger
cholesterol blood level
Apolipoprotein E3
blood level
Transgenic
low density lipoprotein cholesterol
Feces
Mice
high density lipoprotein cholesterol
cholesterol ester transfer protein
dose response
Bile
genetics
plasma clearance
time
lipid transport
hypercholesterolemia
messenger RNA
drug effect
gene expression regulation
particle size
protein function
HDL-cholesterol
Up-Regulation
fat intake
Hyperlipidemia
drug dose comparison
female
Cholesterol
priority journal
Liver
high density lipoprotein
gene activity
APOE*3Leiden.CETP transgenic mice
Antilipemic Agents
mouse strain
protein transport
lipids (amino acids, peptides, and proteins)
triacylglycerol
Drug
kidney
HDL
hypertriglyceridemia
animal experiment
lipoprotein blood level
chemistry
Niacin
animal tissue
Dose-Response Relationship
blood
CETP
drug mechanism
Animals
Humans
controlled study
human
nicotinic acid
antilipemic agent
mouse
Triglycerides
CETP protein
nonhuman
Apolipoprotein A-I
Animal
animal model
disease model
nutritional and metabolic diseases
triacylglycerol blood level
Atherosclerosis
Dietary Fats
Cholesterol Ester Transfer Proteins
carbohydrates (lipids)
transgenic mouse
protein blood level
Disease Models
RNA
metabolism
upregulation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.dris...00893..336cd3489a00fc03763ba18f67b1b240