Granulomatous Reaction to Dermal Injection of Growth Factors from Umbilical Cord Blood-Derived Mesenchymal Stem Cells: A Case Report

Hee Joo Yang, Hyoungmin Na, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Chong Hyun Won Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of KoreaCorrespondence: Chong Hyun WonDepartment of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Republic of KoreaTel +82-2-3010-3460Fax +82-2-486-7831Email drwon@amc.seoul.krAbstract: Use of stem cells to treat various diseases in dermatology has been of interest. Conditioned media with the growth factors secreted from stem cells has been used as a topical agent. We report a case of foreign body granulomas that appeared days after dermal injection of the conditioned media mimicking scars at all injection sites.Keywords: granuloma, growth factor, mesenchymal stem cells, rejuvenation