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Factors Correlating to the Development of Hepatitis C Virus Infection in Hemodialysis Patients—Findings Mainly from Asiatic Populations: A Systematic Review and Meta-Analysis
Factors Correlating to the Development of Hepatitis C Virus Infection in Hemodialysis Patients—Findings Mainly from Asiatic Populations: A Systematic Review and Meta-Analysis
- Source :
- International Journal of Environmental Research and Public Health, Vol 16, Iss 8, p 1453 (2019), International Journal of Environmental Research and Public Health
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Hemodialysis is an effective replacement therapy for chronic renal failure patients. In recent decades, the number of hemodialysis patients has grown rapidly and some measures for preventing blood-borne diseases have been implemented, but hepatitis C virus (HCV) infection remains a significant problem. The meta-analysis published in 2009 on HCV infection-related factors was based on localized study objects, and some additional studies have been published since 2009; however, the contribution of these factors remains under dispute. Our study pooled the odds ratios (ORs) or mean standard deviations (MDs) with 95% confidence intervals (CIs) and analyzed sensitivity using Review Manager 5.1 software (5.1 version Copenhagen: The Nordic Cochrane Centre; 2011) by searching data in the PubMed, Elsevier, Springer, Wiley, and EBSCO databases. Spearman correlation analysis was performed using the SPSS package. In our meta-analysis, 1715 HCV-infected hemodialysis patients and 7093 non-HCV-infected hemodialysis patients from 44 studies were analyzed. The pooled ORs with 95% CIs were: histories of blood transfusion, 4.30 (3.11, 5.96); weekly hemodialysis times > 2, 6.00 (3.25, 11.06); kidney transplantation, 5.80 (3.95, 8.52); hemodialysis units > 2, 6.90 (2.42, 19.68); shared hemodialysis devices, 5.00 (2.35, 10.65); and drug addiction, 4.73 (1.54, 14.47). The pooled MDs with 95% CIs were duration of hemodialysis (months) 27.48 (21.67, 33.30). There was a positive correlation between duration of hemodialysis and the HCV infection rate (p < 0.01). Hemodialysis patients, especially from Asia, with shared hemodialysis devices, hemodialysis units > 2, blood transfusion, kidney transplantation, and drug addiction were at increased risk of HCV infection. The HCV infection rate increased with the duration of hemodialysis. High-risk hemodialysis patients should be monitored and receive timely screening.
- Subjects :
- hepatitis C virus
medicine.medical_specialty
Blood transfusion
Health, Toxicology and Mutagenesis
medicine.medical_treatment
030232 urology & nephrology
lcsh:Medicine
Review
03 medical and health sciences
0302 clinical medicine
Asian People
Renal Dialysis
Risk Factors
Internal medicine
medicine
Humans
Risk factor
Kidney transplantation
hemodialysis
business.industry
lcsh:R
Public Health, Environmental and Occupational Health
Odds ratio
Hepatitis C
medicine.disease
Transplantation
meta-analysis
risk factor
Kidney Failure, Chronic
030211 gastroenterology & hepatology
Hemodialysis
Viral hepatitis
business
Subjects
Details
- Language :
- English
- ISSN :
- 16604601
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....fffde286af52322a8fd69adc5e2b63da