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Mitogenomics of the endemic Ethiopian rats: looking for footprints of adaptive evolution in sky islands
- Source :
- Mitochondrion, Mitochondrion, Elsevier, 2021, 57, pp.182-191. ⟨10.1016/j.mito.2020.12.015⟩
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Organisms living in high altitude must adapt to environmental conditions with hypoxia and low temperature, e.g. by changes in the structure and function of proteins associated with oxidative phosphorylation in mitochondria. Here we analysed the signs of adaptive evolution in 27 mitogenomes of endemic Ethiopian rats (Stenocephalemys), where individual species adapted to different elevation. Significant signals of positive selection were detected in 10 of the 13 mitochondrial protein-coding genes, with a majority of functional substitutions in the NADH dehydrogenase complex. Higher frequency of positively selected sites was found in phylogenetic lineages corresponding to Afroalpine specialists.
- Subjects :
- 0301 basic medicine
Models, Molecular
[SDV]Life Sciences [q-bio]
Oxidative phosphorylation
Mitochondrion
Genetic Introgression
Oxidative Phosphorylation
Evolution, Molecular
Mitochondrial Proteins
03 medical and health sciences
0302 clinical medicine
Animals
Stenocephalemys
Selection, Genetic
Molecular Biology
Gene
NADH dehydrogenase complex
Phylogeny
ComputingMilieux_MISCELLANEOUS
Phylogenetic tree
biology
NADH dehydrogenase
Cell Biology
Sequence Analysis, DNA
biology.organism_classification
Mitochondria
030104 developmental biology
Evolutionary biology
biology.protein
Molecular Medicine
Murinae
Adaptation
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15677249
- Database :
- OpenAIRE
- Journal :
- Mitochondrion, Mitochondrion, Elsevier, 2021, 57, pp.182-191. ⟨10.1016/j.mito.2020.12.015⟩
- Accession number :
- edsair.doi.dedup.....fff9b8ff813cad8c9775610c96a8ebf1