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Radiation-induced circulating miRNA expression in blood of head and neck cancer patients
- Source :
- Radiation and Environmental Biophysics. 59:237-244
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- In recent years, scientists have found evidence confirming the aberrant expression of miRNAs in cancer patients compared to healthy individuals. The growing interest in the identification of non-invasive and specific diagnostic and prognostic molecular markers has identified microRNAs as potential candidates in cancer diagnosis, prognosis and treatment response. In the present study, we have analyzed the expression profile of circulating miR-21, -191 and -421 in peripheral blood of head and neck cancer patients (HNC) to investigate a possible modulation of mRNA levels by radiation and to identify the role of mRNA as biomarkers of cancer prognosis. Results showed a modulation of the microRNA expression at different time points after radiotherapy, suggesting that treatment may influence the release of circulating miRNAs depending also on the time interval elapsed since radiotherapy. The expression levels of miR-21, -191 and -421 were higher in blood of patients treated with radiotherapy alone after 6 months from the end of therapy and high levels of them seemed to correlate with the remission of the disease. The trends shown in this study confirmed that miRNAs could be useful prognosis markers and could provide preliminary data for further evaluation in predicting patients' response to radiotherapy by developing miRNA-based treatments to improve the sensitivity of cancer cells to radiotherapy.
- Subjects :
- Male
Oncology
medicine.medical_specialty
medicine.medical_treatment
Biophysics
Disease
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
microRNA
medicine
Humans
Respiratory system
Aged
General Environmental Science
Aged, 80 and over
Messenger RNA
Radiation
business.industry
X-Rays
Head and neck cancer
Cancer
Middle Aged
Prognosis
medicine.disease
Radiation therapy
MicroRNAs
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Cancer cell
Carcinoma, Squamous Cell
Particle Accelerators
business
Biomarkers
Subjects
Details
- ISSN :
- 14322099 and 0301634X
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Radiation and Environmental Biophysics
- Accession number :
- edsair.doi.dedup.....fff4f87fa463f505a18433905f4f4262