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Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy
- Source :
- Scientific Reports, Liu, Xinfeng; Johnson, Sara; Liu, Shou; Kanojia, Deepak; Yue, Wei; Singn, Udai; et al.(2013). Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy. Scientific Reports, 3. doi: 10.1038/srep02473. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/48z4x620
- Publication Year :
- 2013
-
Abstract
- Cancer stem cells (CSCs) have been identified in primary breast cancer tissues and cell lines. The CSC population varies widely among cancerous tissues and cell lines, and is often associated with aggressive breast cancers. Despite of intensive research, how the CSC population is regulated within a tumor is still not well understood so far. In this paper, we present a mathematical model to explore the growth kinetics of CSC population both in vitro and in vivo. Our mathematical models and supporting experiments suggest that there exist non-linear growth kinetics of CSCs and negative feedback mechanisms to control the balance between the population of CSCs and that of non-stem cancer cells. The model predictions can help us explain a few long-standing questions in the field of cancer stem cell research, and can be potentially used to predict the efficicacy of anti-cancer therapy.
- Subjects :
- Cell signaling
Equilibrium
medicine.medical_treatment
Population
Antineoplastic Agents
Apoptosis
Breast Neoplasms
Cell Communication
Biology
Models, Biological
Article
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Breast cancer
Drug Delivery Systems
Cancer stem cell
medicine
Medicine and Health Sciences
Computer Simulation
Solid Tumors
education
Clonogenic Assays
030304 developmental biology
Cell Proliferation
0303 health sciences
education.field_of_study
Tumorigenicity
Multidisciplinary
Cell growth
Life Sciences
Hypothesis
Line
medicine.disease
3. Good health
Dynamics
Nonlinear Dynamics
030220 oncology & carcinogenesis
Immunology
Cancer cell
Cancer research
Neoplastic Stem Cells
Stem cell
Heterogeneity
Model
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....ffe888b757962a0e9de2867019ecd965