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Effects of an onion-olive oil maceration product containing essential ingredients of the Mediterranean diet on blood pressure and blood fluidity
- Source :
- ResearcherID
- Publication Year :
- 2001
-
Abstract
- Twenty-four patients with arterial hypertension (WHO class I) received either 4 capsules of an onion-olive oil maceration product, containing essential ingredients of the Mediterranean diet, or placebo daily over a period of one week. In order to investigate the acute effect on arterial blood pressure, measurements were performed before and 5 h after the administration of the first dose of 4 capsules verum or placebo, respectively. For the evaluation of the long term effect further blood pressure measurements were performed after one week's treatment with a daily dose of 4 capsules. After a wash-out phase of 2 weeks followed by a crossover, the second study phase, which was identical in design, was carried out. In addition patients were instructed to measure their blood pressure 4 times daily at home for the whole study period. Haemorheological parameters (platelet aggregation, erythrocyte aggregation, plasma viscosity and haematocrit) were also determined at the measuring points mentioned above. The onion-olive oil maceration product led to a significant decrease in systolic blood pressure. There was also a trend towards a decrease in diastolic blood pressure. The improved blood fluidity observed resulted from a decrease in haematocrit. All effects could be shown immediately and after one week's administration.
- Subjects :
- Adult
Male
medicine.medical_specialty
Mediterranean diet
Blood fluidity
Blood Pressure
Placebo
Erythrocyte aggregation
Animal science
Double-Blind Method
Oral administration
Drug Discovery
Onions
medicine
Maceration (wine)
Humans
Plant Oils
Olive Oil
business.industry
Mediterranean Region
Blood flow
Surgery
Diet
Blood pressure
Blood
Hypertension
Female
business
Rheology
Subjects
Details
- ISSN :
- 00044172
- Volume :
- 51
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Arzneimittel-Forschung
- Accession number :
- edsair.doi.dedup.....ffdeec18891f6342b4639371b3f0f634