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Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis
- Source :
- Clinical Interventions in Aging
- Publication Year :
- 2019
-
Abstract
- Discontinuation of denosumab during osteoporosis treatment leads to rapid loss of bone mineral density and induces a bone turnover rebound effect. Previous studies have reported analysis based on dual-energy X-ray absorptiometry scanning (DXA). Here, we report the first case involving analysis of three-dimensional bone mineral density and bone strength, measured by quantitative computed tomography (QCT) after discontinuation of denosumab. An 82-year-old woman who discontinued denosumab because of patient’s wish was administered the fifth dose after a gap of 14 months. Her bone mineral density evaluated by DXA and QCT, bone strength, and bone turnover marker levels showed significant rebound phenomenon. The levels of the cortical parameters of the hip were also decreased indicating an increased risk of femoral fractures after denosumab interruption. Our case highlights the increased risk of fractures after discontinuation of denosumab. Therefore, denosumab must be used judiciously without interruption in the dosage schedule.
- Subjects :
- medicine.medical_specialty
cortical bone
Urology
Case Report
Drug Administration Schedule
Bone remodeling
biomechanical analysis
03 medical and health sciences
0302 clinical medicine
Bone strength
Absorptiometry, Photon
Bone Density
medicine
Humans
030212 general & internal medicine
Quantitative computed tomography
Osteoporosis, Postmenopausal
Femoral neck
Bone mineral
Aged, 80 and over
medicine.diagnostic_test
Bone Density Conservation Agents
business.industry
lumbar spine
femoral neck
General Medicine
Discontinuation
Biomechanical Phenomena
medicine.anatomical_structure
Denosumab
Withholding Treatment
Cortical bone
Female
Geriatrics and Gerontology
business
Tomography, X-Ray Computed
bone turnover markers
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 11781998
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical interventions in aging
- Accession number :
- edsair.doi.dedup.....ffd66ac0e9d6ad102a90c034825279fd