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Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
- Source :
- Memórias do Instituto Oswaldo Cruz, Volume: 104 Supplement 1, Pages: 301-310, Published: JUL 2009, Memórias do Instituto Oswaldo Cruz., Vol 104, Pp 301-310 (2009)
- Publication Year :
- 2009
- Publisher :
- FapUNIFESP (SciELO), 2009.
-
Abstract
- Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
- Subjects :
- Microbiology (medical)
Chagas disease
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Trypanosoma cruzi
lcsh:QR1-502
Disease
Biology
lcsh:Microbiology
Pharmacotherapy
In vivo
medicine
Animals
Humans
experimental chemotherapy
Pentamidine
Public health
medicine.disease
biology.organism_classification
Trypanocidal Agents
In vitro
propolis
naphthoquinones
Drug development
aromatic diamidines
Immunology
N,N-dimethyl-propenamines
Subjects
Details
- ISSN :
- 00740276
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Memórias do Instituto Oswaldo Cruz
- Accession number :
- edsair.doi.dedup.....ffd41c5e2f0bd0d4b7d74008c5c9d498