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Nanoparticle-based immunotherapy: state of the art and future perspectives
- Source :
- Expert review of clinical immunology. 16(5)
- Publication Year :
- 2020
-
Abstract
- For several years now, medicine has been benefiting from the contribution of nanoparticles (NPs) technology for both diagnosis and therapy. They can be used as adjuvants, being capableThe review focuses on experimental use of NPs as adjuvants/carriers for allergen immunotherapy (AIT). Human clinical trials conducted so far are discussed.Results of experimental studies and recent clinical trials support the use of NPs as carrier/adjuvant in AIT. Comparisons between NP-based and classical AIT are needed, to show the usefulness of the NP-based approach. However, there are still unsolved problems: the persistence of non-degradable NPs with possible toxicological consequences, and the formation of the protein corona around the NPs, which could alter their activity and fate. Virus-like particles seem the most promising NPs for allergy treatment, as for other vaccines. Over the next decade, NP-based AIT will be largely used to treat allergic disorders.
- Subjects :
- Allergen immunotherapy
Allergy
Drug Carriers
business.industry
medicine.medical_treatment
fungi
Immunology
technology, industry, and agriculture
food and beverages
Nanoparticle
Nanotechnology
macromolecular substances
Immunotherapy
medicine.disease
Adjuvants, Immunologic
medicine
Hypersensitivity
Immunology and Allergy
Animals
Humans
Nanoparticles
business
Adjuvant
Subjects
Details
- ISSN :
- 17448409
- Volume :
- 16
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert review of clinical immunology
- Accession number :
- edsair.doi.dedup.....ffd369ea05eebd7e4412ae08efd4bc1f