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Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors
- Source :
- Journal of Synchrotron Radiation, Journal of Synchrotron Radiation, 2012, 19 (Pt 4), pp.478-82. ⟨10.1107/S0909049512015105⟩, Journal of Synchrotron Radiation, International Union of Crystallography, 2012, 19 (Pt 4), pp.478-82. ⟨10.1107/S0909049512015105⟩
- Publication Year :
- 2012
-
Abstract
- International audience; Microbeam radiation therapy (MRT), a preclinical form of radiosurgery, uses spatially fractionated micrometre-wide synchrotron-generated X-ray beams. As MRT alone is predominantly palliative for animal tumors, the effects of the combination of MRT and a newly synthesized chemotherapeutic agent JAI-51 on 9L gliosarcomas have been evaluated. Fourteen days (D14) after implantation (D0), intracerebral 9LGS-bearing rats received either MRT, JAI-51 or both treatments. JAI-51, alone or immediately after MRT, was administered three times per week. Animals were kept up to ∼20 weeks after irradiation or sacrificed at D16 or D28 after treatment for cell cycle analysis. MRT plus JAI-51 increased significantly the lifespan compared with MRT alone (p = 0.0367). JAI-51 treatment alone had no effect on rat survival. MRT alone or associated with JAI-51 induced a cell cycle blockade in G2/M (p < 0.01) while the combined treatment also reduced the proportion of G0/G1 cells. At D28 after irradiation, MRT and MRT/JAI-51 had a smaller cell blockade effect in the G2/M phase owing to a significant increase in tumor cell death rate (8c). The combination of MRT and JAI-51 increases the survival of 9LGS-bearing rats by inducing endoreduplication of DNA and tumor cell death; further, it slowed the onset of tumor growth resumption two weeks after treatment.
- Subjects :
- Male
Nuclear and High Energy Physics
medicine.medical_specialty
Chalcone
MESH: Rats
medicine.medical_treatment
MESH: Tubulin
Gliosarcoma
Radiosurgery
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Chalcones
Microbeam radiation therapy
Tubulin
MESH: Radiosurgery
medicine
Tumor cell death
Endoreduplication
Animals
Medical physics
Tumor growth
MESH: Animals
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Instrumentation
MESH: Chalcones
Radiation
business.industry
MESH: Rats, Inbred F344
Brain Neoplasms
Cell cycle
MESH: Male
Rats, Inbred F344
3. Good health
Blockade
Rats
chemistry
030220 oncology & carcinogenesis
MESH: Brain Neoplasms
Cancer research
MESH: Synchrotrons
MESH: Gliosarcoma
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
business
Synchrotrons
Subjects
Details
- ISSN :
- 16005775 and 09090495
- Volume :
- 19
- Issue :
- Pt 4
- Database :
- OpenAIRE
- Journal :
- Journal of synchrotron radiation
- Accession number :
- edsair.doi.dedup.....ffd0c017adfa2f5a4bbdfeca89fff252