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Evolving insights into penile cancer pathology and the eighth edition of the AJCC TNM staging system
- Source :
- Urologic Oncology: Seminars and Original Investigations. 40:215-222
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The majority of penile malignant tumors are squamous cell carcinomas. They are pathologically defined as epithelial neoplasms originating in the squamous cells of the inner mucosal lining of the glans, coronal sulcus or foreskin. Tumor location and site of origin is preferentially in glans (70%) followed by foreskin (25%) and coronal sulcus (5%). Despite the variable geographic distribution, pathological features of penile carcinomas in areas of high- and low-risk are similar. Penile tumors are morphologically heterogeneous. A major advance, based on biological, etiological and prognostic factors, is the 2016 WHO classification separating epithelial penile neoplasia, precancerous and invasive, in non-HPV and HPV-related.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Urology
030232 urology & nephrology
TNM staging system
03 medical and health sciences
Foreskin
0302 clinical medicine
medicine
Humans
Penile cancer
Tumor location
Glans
Penile Neoplasms
Pathological
Neoplasm Staging
business.industry
Papillomavirus Infections
medicine.disease
Geographic distribution
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Penile Intraepithelial Neoplasia
business
Penis
Subjects
Details
- ISSN :
- 10781439
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Urologic Oncology: Seminars and Original Investigations
- Accession number :
- edsair.doi.dedup.....ffc8fa1af50d8505777ba4fa964be5b6